May 26, 2009Proceedings of the National Academy of SciencesOpen Access

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

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Population

cardiac troponin T (cTNT) pre-mRNA

Design

Preclinical

Authors

MWM. Bryan WarfThird Wave Systems (United States)JDJulien V. Diegel PHPeter H. von HippelUniversity of Oregon

Discussion

Member takes

Implication

Does not alter clinical management of myotonic dystrophy; extends mechanistic models of MBNL1 splicing regulation in cTNT.

Structured PICO

Population

cardiac troponin T (cTNT) pre-mRNA

Intervention

MBNL1 binding and RNA secondary structure mutations

Outcome

splicing of exon 5 in the cardiac troponin T (cTNT) pre-mRNAsurrogate

The study elucidates the molecular mechanism by which MBNL1 regulates alternative splicing of cTNT, providing insights into the pathogenesis of Myotonic dystrophy type 1.

Cite This Study

Warf et al. (2009) studied this question.

synapsesocial.com/papers/6a710276f44fa9f079dec63a https://doi.org/10.1073/pnas.0900342106

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The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The protein factors MBNL1 and U2AF65 bind alternative RNA structures to regulate splicing

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider