Key result
MBNL1 forms a ring-like structure that binds to the dsCUG helix with high affinity, providing a mechanistic basis for its sequestration by pathogenic RNAs in myotonic dystrophy.
Authors
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May inform structure-guided therapies in myotonic dystrophy; extends mechanistic models of MBNL1 sequestration but leaves clinical translation open.
Yuan et al. (2007) studied Myotonic dystrophy. MBNL1 forms a ring-like structure that binds to the dsCUG helix with high affinity, providing a mechanistic basis for its sequestration by pathogenic RNAs in myotonic dystrophy.
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