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Anti-human CD3 antibodies are rendered inert with a coating of photolabile 2-nitrobenzyl groups until their activity is restored by irradiation with UVA light, at which point the antibodies are free to bind and activate T-cells. Such antibodies should enable the regulation of cytotoxic T-cell activity at required times and locations in the body. This would have widespread medical application, particularly in the treatment of cancer.
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Self et al. (2007) studied this question.
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