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A photoactivatable anti-murine CD3 antibody was constructed. When reactivated in vivo in the presence of tumour pieces it markedly reduces the growth of ovarian carcinoma. Such antibodies provide a means to target T-cells with a much higher degree of specificity to tumours, whilst minimising side effects in other non-illuminated areas of the body.
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Thompson et al. (2007) studied this question.
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