November 23, 1999Circulation
Statin-Sensitive Dysregulated AT1 Receptor Function and Density in Hypercholesterolemic Men
Why the study?
Does statin therapy reduce AT1 receptor expression and angiotensin II-induced blood pressure elevation in hypercholesterolemic men?
Population
39 men, comprising normocholesterolemic and hypercholesterolemic individuals.
Comparison
Cholesterol-lowering therapy with statins vs Normocholesterolemic men and pre-treatment…
Design
Cohort
Authors
Discussion
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Implication
Statin-associated AT1 downregulation may blunt angiotensin II responses in hypercholesterolemia; leaves open clinical hypertension benefits pending randomized data.
Structured PICO
Does statin therapy reduce AT1 receptor expression and angiotensin II-induced blood pressure elevation in hypercholesterolemic men?
P
Population
39 men, comprising normocholesterolemic (n=19, cholesterol 181+/-11 mg/dL) and hypercholesterolemic (n=20, cholesterol 294+/-10 mg/dL) individuals.
I
Intervention
Cholesterol-lowering therapy with statins (HMG CoA reductase inhibitors)
C
Comparator
Normocholesterolemic men (for baseline comparison) and pre-treatment baseline (for statin intervention)
O
Outcome
Blood pressure increase after infusion of angiotensin II and AT1 receptor expression on isolated plateletssurrogate
Hypercholesterolemia upregulates AT1 receptor expression and function in men, which can be reversed by statin therapy, providing insight into the link between hypercholesterolemia and hypertension.
Cite This Study
Nickenig et al. (1999) studied this question.