Why the study?
Are markers of platelet activation (beta-thromboglobulin, platelet production time) altered in patients with vascular disease compared to healthy controls?
Population
112 patients with vascular disease and 103 healthy controls.
Design
Case-control
Authors
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May indicate platelet activation in PVD/DVT; leaves open whether these assays improve risk stratification or guide therapy.
Are markers of platelet activation (beta-thromboglobulin, platelet production time) altered in patients with vascular disease compared to healthy controls?
Plasma beta-thromboglobulin and platelet production time assays may serve as more specific indicators of in vivo platelet activation than in vitro platelet aggregation tests in patients with peripheral vascular disease and recent deep vein thrombosis.
Cella et al. (1979) studied this question.
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