Why the study?
Does genotype and phenotype influence the biologic response to desmopressin in patients with type 1 von Willebrand disease?
Population
77 patients with type 1 von Willebrand disease (VWD)
Design
Cohort
Authors
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May support genotype-based desmopressin response prediction in type 1 VWD; hypothesis-generating and requires prospective validation.
Does genotype and phenotype influence the biologic response to desmopressin in patients with type 1 von Willebrand disease?
In type 1 VWD, the biologic response to desmopressin is highly dependent on the underlying genetic mutation location.
Castaman et al. (2008) studied this question.
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