May 1, 1999Haemophilia
Diagnosis and management of von Willebrand disease
Why the study?
How is von Willebrand disease diagnosed and managed?
Population
Patients with von Willebrand disease (vWD)
Design
Review
Authors
Discussion
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Member takes
Implication
Guides subtype-specific vWD therapy selection; leaves open prospective validation of concentrate use in type 2/3.
Structured PICO
How is von Willebrand disease diagnosed and managed?
P
Population
Patients with von Willebrand disease (vWD)
I
Intervention
Desmopressin, plasma concentrates containing FVIII and vWF, or platelet concentrates
O
Outcome
Correction of haemostasis defects (abnormal coagulation expressed by low levels of factor VIII and abnormal platelet adhesion expressed by a prolonged bleeding time)
Desmopressin is the primary treatment for type 1 von Willebrand disease, while plasma concentrates are required for types 2 and 3 to correct haemostasis defects.
Cite This Study
Federici et al. (1999) studied this question.