Why the study?
Obesity and diets high in saturated fat increase the risk of arrhythmias and sudden cardiac death, but the underlying molecular mechanisms are not well understood.
Does NOX2 inhibition prevent arrhythmogenic effects of a high saturated fat diet in mice?
Does NOX2 inhibition prevent arrhythmogenic effects of a high saturated fat diet in mice?
NOX2 inhibition prevents arrhythmogenic abnormalities caused by a high saturated fat diet in mice, suggesting a potential novel therapeutic target for lipid overload-induced arrhythmias.
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Supports NOX2 mechanism in diet-induced arrhythmias; leaves open human relevance and clinical dietary guidance.
Joseph et al. (2019) studied this question.
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