Adipokines and inflammation markers and risk of differentiated thyroid carcinoma: The EPIC study
Why the study?
Are serum concentrations of adipokines and inflammation markers associated with the risk of differentiated thyroid carcinoma?
Population
1,491 participants from the European Prospective Investigation into Cancer and Nutrition study, including…
Comparison
Serum concentrations of leptin, adiponectin… vs Lower levels of the respective biomarkers
Design
Case-control
Authors
Discussion
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Member takes
Implication
IL-10 positively and adiponectin inversely associated with TC risk; leaves open whether these markers causally influence differentiated thyroid cancer.
Structured PICO
Are serum concentrations of adipokines and inflammation markers associated with the risk of differentiated thyroid carcinoma?
P
Population
1,491 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, including 475 first primary incident differentiated thyroid cancer (TC) cases (399 women, 76 men) and 1,016 matched cancer-free cohort participants.
I
Intervention
Serum concentrations of leptin, adiponectin, C-reactive protein (CRP), interleukin (IL)-6, IL-10, and tumor necrosis factor (TNF)-alpha
C
Comparator
Lower levels of the respective biomarkers (e.g., Tertile 1)
O
Outcome
Risk of differentiated thyroid cancer (TC)
Higher levels of IL-10 and lower levels of adiponectin are associated with an increased risk of differentiated thyroid cancer in women, suggesting a role for inflammation in its pathogenesis.
Cite This Study
Dossus et al. (2017) studied this question.