Why the study?
Does primary hyperaldosteronism increase myocardial sodium storage compared to healthy controls, and does treatment reduce it?
Population
20 subjects total: 8 patients with primary hyperaldosteronism and 12 normotensive healthy controls.
Comparison
Treatment of primary hyperaldosteronism (PHA) vs Normotensive healthy controls and pre-treatment…
Design
Cohort
Authors
Loading...
Myocardial sodium storage may drive LVH beyond BP in PHA; hypothesis-generating and requires prospective confirmation before clinical translation.
Does primary hyperaldosteronism increase myocardial sodium storage compared to healthy controls, and does treatment reduce it?
23Na MRI demonstrates that the myocardium acts as a novel site of sodium storage in primary hyperaldosteronism, which is reversible with treatment and may explain the link between sodium and left ventricular hypertrophy.
Christa et al. (2018) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: