Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
March 1, 2005Asian Cardiovascular and Thoracic Annals

Anticoagulation in Patients with Mechanical Valves during Pregnancy

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does continuous oral warfarin throughout pregnancy improve safety and efficacy compared to subcutaneous heparin in the 1st trimester followed by warfarin in pregnant women with mechanical heart valves?

Population

250 pregnancies in 245 women with mechanical heart valves

Comparison

Oral warfarin throughout pregnancy, with heparin… vs Subcutaneous heparin in the 1st trimester and…

Design

Cohort

Follow-up

throughout pregnancy and delivery

Authors

MGMuhammad Abid GeelaniGovind Ballabh Pant HospitalSSSandeep SinghIndiana University HealthAVAmitabh VermaPatna Medical College and Hospital

Discussion

Loading...

Member takes

Implication

Continuous warfarin may avoid first-trimester heparin switch without observed fetal malformations; observational data leaves open need for randomized confirmation of maternal safety.

Structured PICO

Does continuous oral warfarin throughout pregnancy improve safety and efficacy compared to subcutaneous heparin in the 1st trimester followed by warfarin in pregnant women with mechanical heart valves?

P
Population
250 pregnancies in 245 women with mechanical heart valves
I
Intervention
Oral warfarin throughout pregnancy, with heparin administered at the time of delivery
C
Comparator
Subcutaneous heparin in the 1st trimester and oral warfarin for the other trimesters, with heparin administered at the time of delivery
O
Outcome
Coumarin-induced fetal malformations, thromboembolic episodes, valve thrombosis, maternal death, and spontaneous abortionsafety

Continuous oral warfarin throughout pregnancy in women with mechanical heart valves appears safe with no observed coumarin-induced fetal malformations, suggesting that switching to heparin in the first trimester may not be mandatory.

Cite This Study

Geelani et al. (2005) studied this question.

synapsesocial.com/papers/6a710bb426a7f98052dd78f4https://doi.org/10.1177/021849230501300107

Topics

Anticoagulation in AF
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Coumarin anticoagulation during pregnancy in patients with mechanical valve prostheses1991 · 57 citations
  2. 2Pregnancy in patients with prosthetic cardiac valve:A 10-Year Experience1988 · 60 citations
  3. 3Cardiac valve prostheses, anticoagulation, and pregnancy.1986 · 50 citations
  4. 4Effects of Coumarin Compounds on the Fetus1970 · 44 citations
  5. 5Prevalence survey for chronic rheumatic heart disease and rheumatic fever in northern India.1972 · 50 citations