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January 19, 2013Journal of Sleep ResearchOpen Access

Association between obstructive sleep apnea severity and endothelial dysfunction in an increased background of cardiovascular burden

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Why the study?

Is increasing obstructive sleep apnea severity associated with worsening endothelial function in patients with cardiovascular burden?

Population

267 individuals with an apnea-hypopnea index of 15-50 and known cardio/cerebrovascular disease or CVD risk…

Design

Cross-sectional

Authors

FSFadi SeifUniversity Hospitals Cleveland Medical CenterSPSanjay R. PatelUniversity of PittsburghHWHarneet K. WaliaBaptist Hospital of Miami

Discussion

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Implication

OSA severity linked to endothelial decline in CV patients; hypothesis-generating and should not yet change practice.

Structured PICO

Is increasing obstructive sleep apnea severity associated with worsening endothelial function in patients with cardiovascular burden?

P
Population
267 individuals with an apnea-hypopnea index (AHI) of 15-50 and known cardio/cerebrovascular disease (CVD) or CVD risk factors, recruited from cardiology clinics at four sites.
O
Outcome
Endothelium-mediated vasodilatation (Framingham reactive hyperaemia index [F-RHI] derived from peripheral arterial tonometry [PAT])surrogate

Higher levels of intermittent hypoxemia in obstructive sleep apnea are associated with a graded decline in endothelial function among patients with cardiovascular burden.

Cite This Study

Seif et al. (2013) studied this question.

synapsesocial.com/papers/6a710c78ac440176ef29b8f3https://doi.org/10.1111/jsr.12026

Topics

Women and heart disease
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