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January 1, 2015Circulation JournalOpen Access

Association Between Endothelial Function (Assessed on Reactive Hyperemia Peripheral Arterial Tonometry) and Obstructive Sleep Apnea, Visceral Fat Accumulation, and Serum Adiponectin

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Why the study?

Does CPAP treatment improve endothelial function in patients with severe obstructive sleep apnea?

Population

133 patients evaluated after polysomnography, including a subgroup of 44 patients with severe obstructive…

Comparison

Continuous positive airway pressure treatment… vs Baseline (before CPAP treatment)

Design

Cohort

Follow-up

3 months

Authors

MAMasanori AzumaSaiseikai Nakatsu HospitalYCYuichi ChiharaKyoto Medical CenterCYChikara YoshimuraFukuoka University

Discussion

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Implication

CPAP may benefit endothelial function in severe OSA; leaves open need for RCTs to confirm causality.

Structured PICO

Does CPAP treatment improve endothelial function in patients with severe obstructive sleep apnea?

P
Population
133 patients evaluated after polysomnography, including a subgroup of 44 patients with severe obstructive sleep apnea (AHI ≥30)
I
Intervention
Continuous positive airway pressure (CPAP) treatment for 3 months
C
Comparator
Baseline (before CPAP treatment)
O
Outcome
Endothelial function evaluated as reactive hyperemia index (RHI) on reactive hyperemia peripheral arterial tonometrysurrogate

Severe obstructive sleep apnea is independently associated with endothelial dysfunction, which is reversible after 3 months of CPAP therapy.

Cite This Study

Azuma et al. (2015) studied this question.

synapsesocial.com/papers/6a710c78ac440176ef29b8echttps://doi.org/10.1253/circj.cj-14-1303

Topics

Hypertension managementLipid management
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