August 19, 2015PLoS ONEOpen Access

The Fecal Virome of Children with Hand, Foot, and Mouth Disease that Tested PCR Negative for Pathogenic Enteroviruses

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Population

29 Thai children with clinical diagnosis of Hand, Foot, and Mouth Disease collected during the 2012…

Design

Cross-sectional

Authors

PLPiyada LinsuwanonArmed Forces Research Institute of Medical Science YPYong PoovorawanThammasat University LLLinlin LiZhengzhou University

Discussion

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Implication

Metagenomics reveals diverse viruses in enterovirus-negative HFMD; leaves open their etiologic roles pending validation.

Structured PICO

Population

29 Thai children with clinical diagnosis of Hand, Foot, and Mouth Disease (HFMD) collected during the 2012 outbreak, previously tested negative by PCR for enterovirus 71 and coxsackievirus A16 and A6.

Intervention

Viral metagenomic approach (deep sequencing)

Outcome

Identification of eukaryotic viruses in fecal samples

Deep sequencing of fecal samples from children with HFMD who tested negative for common enteroviruses revealed a broad diversity of other viruses, including human rhinovirus C, astrovirus-MLB2, and coxsackievirus A21.

Cite This Study

Linsuwanon et al. (2015) studied this question.

synapsesocial.com/papers/6a710d2f5671bbf00bc2d2ae https://doi.org/10.1371/journal.pone.0135573

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The Fecal Virome of Children with Hand, Foot, and Mouth Disease that Tested PCR Negative for Pathogenic Enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The Fecal Virome of Children with Hand, Foot, and Mouth Disease that Tested PCR Negative for Pathogenic Enteroviruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider