February 1, 1992Antimicrobial Agents and ChemotherapyOpen Access

Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound

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Population

Human rhinovirus 9 (HRV 9) and a semiresistant variant HRV 9H

Design

Preclinical

Authors

MMM. MoeremansJanssen (Belgium)MRMarc De RaeymaekerGoethe University Frankfurt GDG. DaneelsJohnson & Johnson (United States)

Discussion

Member takes

Implication

May guide HRV capsid inhibitor design; leaves open translation to human efficacy.

Structured PICO

Population

Human rhinovirus 9 (HRV 9) and a semiresistant variant HRV 9H

Intervention

Antiviral compound R 61837

Outcome

Binding parameters (Kd) and capsid-stabilizing activitysurrogate

R 61837 exhibits strong, poorly reversible binding to HRV 9, stabilizing the viral capsid and preventing conformational changes necessary for infection.

Cite This Study

Moeremans et al. (1992) studied this question.

synapsesocial.com/papers/6a710d315671bbf00bc2d2b8 https://doi.org/10.1128/aac.36.2.417

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Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Study of the parameters of binding of R 61837 to human rhinovirus 9 and immunobiochemical evidence of capsid-stabilizing activity of the compound

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider