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January 1, 1992Antimicrobial Agents and ChemotherapyOpen Access

In vitro activity of pirodavir (R 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity

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Population

In vitro rhinovirus (100 serotypes) and enterovirus (16 serotypes)

Comparison

Pirodavir (R 77975) vs R 61837 (predecessor compound)

Design

Preclinical

Authors

KAKoen AndriesRutgers, The State University of New JerseyBDB. DewindtJanssen (Belgium)JSJos SnoeksRoyal Museum for Central Africa

Discussion

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Implication

Supports preclinical development of capsid binders; leaves open translation to clinical efficacy in humans.

Structured PICO

P
Population
In vitro rhinovirus (100 serotypes) and enterovirus (16 serotypes)
I
Intervention
Pirodavir (R 77975)
C
Comparator
R 61837 (predecessor compound)
O
Outcome
Viral inhibition (EC80)surrogate

Pirodavir is a novel capsid-binding antipicornavirus agent with potent in vitro activity against both group A and group B rhinovirus serotypes.

Cite This Study

Andries et al. (1992) studied this question.

synapsesocial.com/papers/6a710d315671bbf00bc2d2b9https://doi.org/10.1128/aac.36.1.100
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Also Consider

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