Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1‐mediated gene expression in vivo

Monte S. Willis; Kristine M. Wadosky; Jessica Rodriguez; Jonathan C. Schisler; Pamela Lockyer; Eleanor Hilliard; David J. Glass; Cam Patterson

doi:10.1002/cbf.2969

March 20, 2013Cell Biochemistry and FunctionOpen Access

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1‐mediated gene expression in vivo

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Structured PICO

P

Population

Mice models including MuRF1/MuRF2 double null (DN), mice missing three of four alleles (MuRF1(-/-) //MuRF2(+/-) or MuRF1(+/-) //MuRF2(-/-)), and wild-type mice

I

Intervention

Genetic knockout of all four MuRF1 and MuRF2 alleles (double null)

C

Comparator

Wild-type mice and mice missing three of the four alleles

O

Outcome

Cardiac phenotype (hypertrophic cardiomyopathy and heart failure) and differential gene expressionsurrogate

MuRF1 and MuRF2 play a redundant but essential role in normal cardiac development and physiologic hypertrophy by regulating E2F transcription factor localization.

Implication

MuRF1/MuRF2-E2F axis may drive cardiomyopathy; hypothesis-generating for human therapies, with clinical relevance unproven.

Discussion

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Cite This Study

Willis et al. (2013) studied this question.

synapsesocial.com/papers/6a710d40e36a167817e2e0ae https://doi.org/10.1002/cbf.2969

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Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1‐mediated gene expression in vivo

Structured PICO

Implication

Discussion

Cite This Study

Muscle ring finger 1 and muscle ring finger 2 are necessary but functionally redundant during developmental cardiac growth and regulate E2F1‐mediated gene expression in vivo

Structured PICO

Implication

Discussion

Cite This Study

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