February 6, 2004AJP Heart and Circulatory Physiology

Adult rat cardiomyocytes exhibit capacitative calcium entry

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Population

Adult rat ventricular myocytes

Design

Preclinical

Authors

DHDacia L. HuntonHoward Hughes Medical Institute LZLuyun ZouUniversity of Alabama at Birmingham YPYi PangGuangdong Pharmaceutical University

Discussion

Member takes

Implication

Demonstrates CCE in adult rat cardiomyocytes; leaves open its role in human cardiac Ca2+ handling and disease.

Structured PICO

Population

Adult rat ventricular myocytes

Intervention

Depletion of sarcoplasmic reticulum Ca(2+) stores using Ca(2+)-ATPase inhibitors coupled with Ca(2+) ionophores, angiotensin II, or caffeine

Outcome

Presence and characteristics of capacitative Ca(2+) entry (CCE) measured via Ca(2+)-sensitive dyes and whole-cell patch clampsurrogate

Adult rat cardiomyocytes exhibit capacitative calcium entry upon depletion of sarcoplasmic reticulum stores, suggesting a role in physiological responses to phospholipase C-generating agonists.

Cite This Study

Hunton et al. (2004) studied this question.

synapsesocial.com/papers/6a710dc5febe604dd709c7a5 https://doi.org/10.1152/ajpheart.00162.2003

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Bookmark

Adult rat cardiomyocytes exhibit capacitative calcium entry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adult rat cardiomyocytes exhibit capacitative calcium entry

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider