Key result
Proliferating human pulmonary artery smooth muscle cells exhibited a fivefold greater transient rise in cytosolic free Ca2+ due to capacitative Ca2+ entry compared to growth-arrested cells.
Why the study?
Does cell proliferation enhance capacitative Ca2+ entry in human pulmonary artery smooth muscle cells?
Population
Human pulmonary artery smooth muscle cells (PASMCs)
Comparison
Cyclopiazonic acid and addition of 1.8 mM… vs Growth-arrested human PASMCs
Design
Preclinical
Authors
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May link capacitative Ca2+ entry to pulmonary vascular remodeling; leaves open therapeutic targeting in pulmonary hypertension.
Does cell proliferation enhance capacitative Ca2+ entry in human pulmonary artery smooth muscle cells?
Effect estimate: fivefold greater
Augmented capacitative Ca2+ entry is associated with the proliferation of human pulmonary artery smooth muscle cells and may play a role in stimulating and maintaining cell growth.
Vera A. Golovina (1999) studied Cell proliferation in human pulmonary artery smooth muscle cells. Cell proliferation vs. Growth-arrested state was evaluated on Transient rise of [Ca(2+)](cyt) due to capacitative Ca(2+) entry (fivefold greater). Proliferating human pulmonary artery smooth muscle cells exhibited a fivefold greater transient rise in cytosolic free Ca2+ due to capacitative Ca2+ entry compared to growth-arrested cells.
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