February 1, 2001AJP Heart and Circulatory Physiology

UpregulatedTRPand enhanced capacitative Ca2+entry in human pulmonary artery myocytes during proliferation

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Population

Human pulmonary arterial smooth muscle cells (PASMC)

Comparison

Proliferation conditions vs Growth-arrested cells

Design

Preclinical

Authors

VGVera A. GolovinaUniversity of Maryland, Baltimore OPOleksandr PlatoshynVascular / Pulmonary Vascular CBColleen BaileySunnybrook Health Science Centre

Discussion

Member takes

Implication

Hypothesis-generating for hTRP1-mediated CCE in PASMC proliferation; leaves open therapeutic targeting in pulmonary vascular disease.

Structured PICO

Population

Human pulmonary arterial smooth muscle cells (PASMC)

Intervention

Proliferation conditions (media containing serum and growth factors)

Comparator

Growth-arrested cells

Outcome

Cytosolic Ca2+ concentration ([Ca2+]cyt), capacitative Ca2+ entry (CCE), store-operated Ca2+ channel activity, and hTRP1 mRNA expressionsurrogate

Capacitative Ca2+ entry via hTRP1-encoded channels plays an important role in maintaining elevated cytosolic and stored Ca2+ required for human pulmonary arterial smooth muscle cell proliferation.

Cite This Study

Golovina et al. (2001) studied this question.

synapsesocial.com/papers/6a7ca9dc263fc0f117fab5f0 https://doi.org/10.1152/ajpheart.2001.280.2.h746

View Full Paper

Ask AI

Bookmark

UpregulatedTRPand enhanced capacitative Ca2+entry in human pulmonary artery myocytes during proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

UpregulatedTRPand enhanced capacitative Ca2+entry in human pulmonary artery myocytes during proliferation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider