Periarteriolar and tissue PO2 during sympathetic escape in skeletal muscle

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Population

Exteriorized cat sartorius muscle model

Comparison

Sympathetic nerve stimulation under low O2… vs Sympathetic nerve stimulation under high O2…

Design

Preclinical

Authors

Discussion

Parenchymal PO2 may mediate sympathetic escape in muscle; leaves open translation to human vasoregulation or therapy.

Population

Exteriorized cat sartorius muscle model

Intervention

Sympathetic nerve stimulation under low O2 suffusate (equilibrated with 5% CO2-95% N2)

Comparator

Sympathetic nerve stimulation under high O2 suffusate (10% O2-5% CO2-85% N2)

Outcome

Periarteriolar PO2, parenchymal tissue PO2, and arteriolar diameter (vascular escape)surrogate

Sympathetic escape in skeletal muscle appears to be mediated by a fall in parenchymal cell PO2 rather than vascular wall PO2.

Boegehold et al. (1988) studied this question.

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