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September 22, 2016Nature CommunicationsOpen Access

A polyvalent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

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Why the study?

Does a polyvalent inactivated HRV vaccine induce broad neutralizing antibody responses in mice and rhesus macaques?

Population

Mice and rhesus macaques

Design

Preclinical

Authors

SLSujin LeeMassachusetts General HospitalMNMinh-Thuy NguyenLaboratoire Eau, Environnement et Systèmes UrbainsMCMichael G. CurrierEmory University

Discussion

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Implication

Supports pursuit of polyvalent HRV vaccines; leaves open clinical translation and protection in humans.

Structured PICO

Does a polyvalent inactivated HRV vaccine induce broad neutralizing antibody responses in mice and rhesus macaques?

P
Population
Mice and rhesus macaques
I
Intervention
Polyvalent inactivated human rhinovirus (HRV) vaccine (up to 25-valent in mice and 50-valent in rhesus macaques) plus alhydrogel (alum) adjuvant
O
Outcome
Virus-neutralizing antibody (nAb) responsessurrogate

A polyvalent inactivated rhinovirus vaccine can induce broad neutralizing antibody responses in preclinical models, suggesting feasibility for a common cold vaccine.

Cite This Study

Lee et al. (2016) studied this question.

synapsesocial.com/papers/6a710e0e35aa2c282ce25f1bhttps://doi.org/10.1038/ncomms12838
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Also Consider

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  3. 3Effect of Neutralizing Antibody on Experimental Rhinovirus Infection1963 · 51 citations
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