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May 17, 2016Open Access

50-valent inactivated rhinovirus vaccine is broadly immunogenic in rhesus macaques

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Why the study?

Does a polyvalent inactivated HRV vaccine induce broad neutralizing antibody responses in mice and rhesus macaques?

Population

Mice and rhesus macaques

Design

Preclinical

Authors

SLSujin LeeMassachusetts General HospitalMNMinh-Thuy NguyenLaboratoire Eau, Environnement et Systèmes UrbainsMCMichael G. CurrierEmory University

Discussion

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Implication

Supports advancing polyvalent inactivated HRV vaccines; leaves open clinical protection against common cold.

Structured PICO

Does a polyvalent inactivated HRV vaccine induce broad neutralizing antibody responses in mice and rhesus macaques?

P
Population
Mice and rhesus macaques
I
Intervention
Polyvalent inactivated human rhinovirus (HRV) vaccine (up to 25-valent in mice and 50-valent in rhesus macaques) plus alhydrogel (alum) adjuvant
O
Outcome
Serum virus-neutralizing antibody (nAb) responsessurrogate

A 50-valent inactivated rhinovirus vaccine can induce broad neutralizing antibody responses in rhesus macaques, suggesting that a pan-rhinovirus vaccine may be feasible.

Cite This Study

Lee et al. (2016) studied this question.

synapsesocial.com/papers/6a710e0e35aa2c282ce25f1chttps://doi.org/10.1101/053967
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