Genetic clustering of all 102 human rhinovirus prototype strains: serotype 87 is close to human enterovirus 70

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Population

102 human rhinovirus (HRV) prototype strains and 61 recently isolated Finnish field strains

Design

Preclinical

Authors

Discussion

Refines HRV taxonomy with two main groups and enterovirus reclassification of serotype 87; leaves open diagnostic and therapeutic implications.

Population

102 human rhinovirus (HRV) prototype strains and 61 recently isolated Finnish field strains

Intervention

Genomic sequencing in the VP4/VP2 region and phylogenetic analysis

Outcome

Genetic relationships and clustering of HRV prototype strainssurrogate

Phylogenetic analysis of HRV strains reveals two main genetic groups and shows that serotype 87 is closely related to human enterovirus 70.

larger numbers of field isolates of known serotype need to be characterized, possibly also in the VP1 region

Savolainen et al. (2002) studied this question.

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Refines HRV taxonomy with two main groups and enterovirus reclassification of serotype 87; leaves open diagnostic and therapeutic implications.