July 21, 2004Journal of General Virology

Sequence analysis of human rhinoviruses in the RNA-dependent RNA polymerase coding region reveals large within-species variation

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Population

48 human rhinovirus (HRV) prototype strains and 12 field isolates

Design

Preclinical

Authors

CSCarita SavolainenInstitute for Molecular Medicine Finland PLPia LaineUniversity of Helsinki MMMick N. MuldersWorld Health Organization

Discussion

Member takes

Implication

May necessitate expanded HRV genomic surveillance beyond capsid regions; leaves open clinical or therapeutic relevance of 3D diversity.

Structured PICO

Population

48 human rhinovirus (HRV) prototype strains and 12 field isolates

Intervention

Sequence analysis of the RNA-dependent RNA polymerase (3D polymerase)-coding gene

Outcome

Phylogenetic clustering and intraspecies variation

Within-species variation in the 3D region of human rhinoviruses is greater than in human enteroviruses and exceeds variation in the capsid-coding region.

Cite This Study

Savolainen et al. (2004) studied this question.

synapsesocial.com/papers/6a7390656cf7a6ca1f6c3def https://doi.org/10.1099/vir.0.79897-0

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Sequence analysis of human rhinoviruses in the RNA-dependent RNA polymerase coding region reveals large within-species variation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Sequence analysis of human rhinoviruses in the RNA-dependent RNA polymerase coding region reveals large within-species variation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider