Why the study?
Whether microvascular function is affected in the intact human circulation during cancer radiation therapy had not yet been determined, despite radiotherapy increasing ischemic heart disease risk.
Does unilateral chest radiation therapy impair microvascular endothelial function in women with breast cancer?
Population
Women currently receiving unilateral chest adjuvant radiation therapy for breast cancer (n = 7 part 1, n = 8 part 2)
Comparison
Site of radiation treatment vs contralateral control non-radiated site
Design
Within-patient comparative study
Authors
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Impaired microvascular endothelial function during breast cancer radiotherapy signals early vascular injury; leaves open links to long-term ischemic risk.
Does unilateral chest radiation therapy impair microvascular endothelial function in women with breast cancer?
Chest radiation therapy for breast cancer is associated with early endothelium-dependent microvascular dysfunction at the radiated site.
Banister et al. (2021) studied this question.
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