Why the study?
Does prior radiation therapy impair endothelium-dependent relaxation in human cervical arteries?
Population
Human cervical arteries from patients who had radiation therapy and patients who did not receive radiation…
Comparison
Prior radiation therapy vs No prior radiation therapy (control arteries)
Design
Preclinical
Authors
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Radiation-induced eNOS loss may underlie vascular complications in animal models; leaves open translation to human post-radiation stenosis.
Does prior radiation therapy impair endothelium-dependent relaxation in human cervical arteries?
Radiation therapy impairs nitric oxide- and prostacyclin-mediated endothelium-dependent relaxation in human cervical arteries due to a lack of eNOS expression, which may explain vascular stenosis and poor wound healing in irradiated tissues.
Sugihara et al. (1999) studied this question.
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