Why the study?
Do acetylcholine, A23187, vasoactive intestinal peptide, and peptide histidine methionine induce endothelium-dependent relaxation in isolated human blood vessels?
Population
Isolated human blood vessels obtained from surgical resection material
Design
Preclinical
Authors
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Endothelium-dependent responses in animal vessels should not inform human practice; leaves open translation of coronary contractile patterns to clinical settings.
Do acetylcholine, A23187, vasoactive intestinal peptide, and peptide histidine methionine induce endothelium-dependent relaxation in isolated human blood vessels?
This study demonstrates that endothelium-dependent relaxation mechanisms in human arteries resemble those in other species, with notable contractile responses in coronary arteries.
Thom et al. (1987) studied this question.
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