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Renin dissociation patterns in hypertensive rat models warrant no clinical action; leaves open renal contributions to plasma renin elevation for mechanistic study.
Plasma renin activity increased after the development of hypertension in spontaneously hypertensive (SH) rats, while kidney renin content diminished. However, no difference could be detected in renin activity in renal venous blood of 8-12-week-old SH rats compared to normotensive Wistar rats.
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Jong et al. (1972) studied this question.
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