July 1, 1989AJP Heart and Circulatory Physiology
Electrical uncoupling and impulse propagation in isolated sheep Purkinje fibers
Population
Isolated sheep Purkinje fibers and a computer model of 90 electrically coupled heart cells
Design
Preclinical
Authors
Discussion
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Implication
No immediate clinical implications from this animal model; extends evidence linking intracellular resistance to conduction delay.
Structured PICO
P
Population
Isolated sheep Purkinje fibers and a computer model of 90 electrically coupled heart cells
I
Intervention
Superfusion with heptanol (1.5-3.0 mM), ouabain (0.1-0.5 mM), hypertonic Tyrode solution (up to 600 mM sucrose), or KCl (4 to 20 mM)
O
Outcome
Action potential propagation, conduction velocity (theta), upstroke velocity (Vmax), and intracellular resistance (Ri)surrogate
This preclinical study demonstrates that alterations in electrical coupling and gap junction resistance significantly impact cardiac action potential propagation and conduction velocity.
Cite This Study
Jalife et al. (1989) studied this question.