Population
Guinea-pig ileum (permeabilized muscle strips and intact tissue strips)
Comparison
Kinase inhibitors (Y-27632, HA1077, H-7) vs Control conditions (absence of inhibitors)
Design
Preclinical
Authors
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No immediate clinical implications from animal tissue; leaves open translation of ROK-MLCP mechanisms to human smooth muscle disorders.
Rho-associated kinase (ROK) activation is essential for the tonic phase of agonist-induced smooth muscle contraction by inhibiting myosin light chain phosphatase (MLCP) activity through phosphorylation of MYPT.
Swärd et al. (2000) studied this question.
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