January 1, 2003Journal of the American Society of NephrologyOpen Access

Rho-Kinase Inhibition Blunts Renal Vasoconstriction Induced by Distinct Signaling Pathways In Vivo

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Population

Split hydronephrotic rat kidney model (in vivo)

Comparison

Local application of Rho-kinase inhibitors… vs No ROK inhibition or protein kinase C inhibition…

Design

Preclinical

Authors

ACAlessandro CavarapeUniversity of Udine NENicole EndlichUniversitätsmedizin Greifswald RARoberta AssaloniOspedale di Monfalcone

Discussion

Member takes

Implication

ROK inhibition may blunt experimental renal vasoconstriction; hypothesis-generating in animal data only and should not change practice.

Structured PICO

Population

Split hydronephrotic rat kidney model (in vivo)

Intervention

Local application of Rho-kinase (ROK) inhibitors Y-27632 or HA-1077

Comparator

No ROK inhibition (vasoconstrictors alone) or protein kinase C inhibition with Ro 31-8220

Outcome

Vasoconstriction (glomerular blood flow and vascular diameters) and vascular F-actin distributionsurrogate

Rho-kinase inhibition effectively blunts renal vasoconstriction induced by multiple distinct signaling pathways without affecting F-actin structure, suggesting potential as a treatment for renal vasoconstriction.

Cite This Study

Cavarape et al. (2003) studied this question.

synapsesocial.com/papers/6a705bb8febe604dd7092522 https://doi.org/10.1097/01.asn.0000039568.93355.85

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Rho-Kinase Inhibition Blunts Renal Vasoconstriction Induced by Distinct Signaling Pathways In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rho-Kinase Inhibition Blunts Renal Vasoconstriction Induced by Distinct Signaling Pathways In Vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider