Why the study?
Does fasudil improve ACE2 activity and reduce remodeling proteins in DOCA hypertensive rats?
Population
Deoxycorticosterone acetate (DOCA) hypertensive rats and sham control animals
Comparison
Fasudil (specific Rho kinase inhibitor) vs Untreated hypertensive DOCA rats and sham…
Design
Preclinical
Authors
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Supports Rho kinase inhibition to enhance ACE2 in experimental hypertension; leaves open clinical translation to human disease.
Does fasudil improve ACE2 activity and reduce remodeling proteins in DOCA hypertensive rats?
Rho kinase inhibition with fasudil reduces blood pressure, increases ACE2 activity, and reduces remodeling proteins in experimental hypertension.
Ocaranza et al. (2011) studied this question.
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