Population
Male New Zealand genetically hypertensive rats (NZGH)
Comparison
Castration or castration + testosterone… vs Sham operation
Design
Preclinical
Authors
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May inform Rho kinase-targeted therapies in androgen-sensitive hypertension; extends rat-model mechanisms but leaves open human translation.
Androgens potentiate Ang II-induced renal vascular responses via up-regulation of the Rho kinase signaling pathway in a hypertensive rat model.
SONG et al. (2006) studied this question.
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