Why the study?
Does testosterone play a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats?
Population
Eight-week-old male Wistar rats
Comparison
Castration with or without testosterone… vs Sham operation with Angiotensin II or saline…
Design
Preclinical
Follow-up
28 days of infusion
Authors
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Testosterone modulation warrants no clinical action; leaves open its permissive role in human Ang II hypertension.
Does testosterone play a permissive role in angiotensin II-induced hypertension and cardiac hypertrophy in male rats?
Testosterone plays a permissive role in the development and maintenance of Angiotensin II-induced vascular dysfunction, hypertension, and cardiac hypertrophy in male rats.
Mishra et al. (2018) studied this question.
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