Why the study?
Does castration reduce ANG II-induced MAP and RVR responses in male NZGH rats?
Population
Male New Zealand genetically hypertensive (NZGH) rats obtained at 5 weeks of age
Comparison
Castration with or without testosterone… vs Sham operation (Sham)
Design
Preclinical
Follow-up
Studied at 6-7, 11-12, and 16-17 weeks of age
Authors
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Hypothesis-generating for androgen facilitation of ANG II hypersensitivity in male hypertension; requires translational studies before any clinical inference.
Does castration reduce ANG II-induced MAP and RVR responses in male NZGH rats?
Androgens modulate renal and systemic vascular responsiveness to ANG II, which may contribute to androgen-induced facilitation of hypertension in male NZGH rats.
Song et al. (2006) studied this question.
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