October 18, 2006Journal of Gastroenterology and Hepatology

Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis

View Full Paper

Ask AI

Bookmark

Population

Rats fed a choline-deficient/L-amino acid-defined (CDAA) diet and isolated hepatic stellate cells

Comparison

Rho kinase inhibitor and angiotensin II receptor… vs Untreated CDAA-fed rats and untreated isolated…

Design

Preclinical

Authors

KKKumi Kitamura STShinichiro TadaKeio University Hospital NNNobuhiro NakamotoKeio University

Discussion

Member takes

Implication

Caution against clinical use in liver disease; leaves open Rho kinase inhibition as a target for human studies.

Structured PICO

Population

Rats fed a choline-deficient/L-amino acid-defined (CDAA) diet and isolated hepatic stellate cells

Intervention

Rho kinase inhibitor (Y-27632) and angiotensin II receptor blocker (TCV-116 in vivo, CV-11974 in vitro)

Comparator

Untreated CDAA-fed rats and untreated isolated hepatic stellate cells

Outcome

Liver fibrosis and steatosis, hepatic stellate cell activation, free radical production (4-hydroxynonenal and 8-hydroxy-2'-deoxyguanosine), and mRNA expression of tumor necrosis factor-alpha, transforming growth factor-beta, and alpha-smooth muscle actinsurrogate

The Rho/Rho kinase pathway is involved in the renin-angiotensin system and plays a key role in hepatic fibrosis and steatosis, highlighting a potential therapeutic target.

Cite This Study

Kitamura et al. (2006) studied this question.

synapsesocial.com/papers/6a7d614545db7d096f6e4f84 https://doi.org/10.1111/j.1440-1746.2006.04735.x

View Full Paper

Ask AI

Bookmark

Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Rho/Rho kinase is a key enzyme system involved in the angiotensin II signaling pathway of liver fibrosis and steatosis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider