Why the study?
Does the Rho-kinase inhibitor Y-27632 improve cardiac contractility and prevent cardiovascular remodeling in a rat model of congestive heart failure?
Population
Dahl salt-sensitive hypertensive rats with congestive heart failure (CHF)
Comparison
Specific Rho-kinase inhibitor Y-27632… vs Untreated CHF rats
Design
Preclinical
Follow-up
7 weeks
Authors
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May support Rho-kinase inhibition in experimental CHF; leaves open human translation and requires clinical trials.
Does the Rho-kinase inhibitor Y-27632 improve cardiac contractility and prevent cardiovascular remodeling in a rat model of congestive heart failure?
Inhibition of the Rho-kinase pathway with Y-27632 ameliorates cardiac dysfunction and cardiovascular remodeling in a rat model of congestive heart failure, suggesting a potential therapeutic target.
Naohiko Kobayashi (2002) studied this question.
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