Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
February 28, 2019Frontiers in Cardiovascular MedicineOpen Access

First Report of the Italian Registry on Immune-Mediated Congenital Heart Block (Lu.Ne Registry)

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Neonatal lupus is a rare condition requiring multidisciplinary registries to improve clinical knowledge of immune-mediated congenital heart block.

Do fluorinated steroids improve survival in fetuses with immune-mediated congenital heart block?

Comparison

Fluorinated steroids vs no fluorinated steroids

Design

Retrospective registry-based study

Authors

MFMicaela FrediBrescia UniversityLALaura AndréoliInstitute for Rheumatic Diseases (Japan)BBBeatrice BaccoA. O. Ordine Mauriziano di Torino

Discussion

Loading...

Member takes

Implication

Supports multidisciplinary NL-CHB registries; leaves open optimal prevention and management strategies.

Structured PICO

Do fluorinated steroids improve survival in fetuses with immune-mediated congenital heart block?

P
Population
89 cases of congenital heart block (CHB) in 85 women with 88 pregnancies. Inclusion criteria: maternal confirmed positivity for anti-SSA/Ro and/or anti-SSB/La antibodies, and presence of II or III degree CHB in utero or neonatal period (up to 30 days after birth).
I
Intervention
Fluorinated steroids (administered in 71.4% of pregnancies)
C
Comparator
No fluorinated steroids
O
Outcome
Mortality (fetal, perinatal, and childhood) and permanent pacemaker implantationhard clinical

In a retrospective Italian registry of immune-mediated congenital heart block, mortality was 25.8% and nearly 70% of survivors required a pacemaker, with fluorinated steroid therapy showing no survival benefit.

Cite This Study

Fredi et al. (2019) studied this question.

synapsesocial.com/papers/6a71129e5d37378ac1de3bf5https://doi.org/10.3389/fcvm.2019.00011
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Utility of Cardiac Monitoring in Fetuses at Risk for Congenital Heart Block2008 · 312 citations
  2. 2Maternal and Fetal Factors Associated With Mortality and Morbidity in a Multi–Racial/Ethnic Registry of Anti-SSA/Ro–Associated Cardiac Neonatal Lupus2011 · 317 citations
  3. 3Risk of congenital complete heart block in newborns of mothers with anti-Ro/SSA antibodies detected by counterimmunoelectrophoresis: A prospective study of 100 women2001 · 492 citations
  4. 4Recurrence rates of cardiac manifestations associated with neonatal lupus and maternal/fetal risk factors2009 · 165 citations
  5. 5Outcome of pregnancies in patients with anti‐SSA/Ro antibodies: A study of 165 pregnancies, with special focus on electrocardiographic variations in the children and comparison with a control group2004 · 193 citations