This review highlights the critical role of ribosomal RNA gene transcription in increasing ribosomal capacity during skeletal muscle hypertrophy.
Ribosomal RNA transcription may drive hypertrophy in models; hypothesis-generating and should not yet change practice.
An increase in ribosomal capacity is a hallmark of the hypertrophying muscle. We review evidence demonstrating that transcription of ribosomal RNA genes is necessary for the increase in ribosomal capacity, and this is critical for muscle growth in human and animal models of hypertrophy.
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Kim et al. (2019) studied this question.
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