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Ribosome biogenesis hypothesis remains untested in humans; leaves open its necessity for hypertrophy and warrants prospective validation before any training implications.
Muscle hypertrophy occurs when the rate of protein synthesis exceeds the rate of degradation. A main factor determining the rate of protein synthesis is ribosome abundance or translational capacity. The production of ribosomes is a primary determinant of translational capacity. Based on studies from our laboratory, we propose the novel hypothesis that ribosome biogenesis is necessary for skeletal muscle hypertrophy.
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Wen et al. (2016) studied this question.
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