What question did this study set out to answer?

This research aims to investigate changes in muscle protein turnover during hypertrophy in fowl. It examines how protein synthesis and breakdown rates respond to added weight.

November 15, 1978Biochemical JournalOpen Access

Turnover of muscle protein in the fowl. Changes in rates of protein synthesis and breakdown during hypertrophy of the anterior and posterior latissimus dorsi muscles

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This research aims to investigate changes in muscle protein turnover during hypertrophy in fowl. It examines how protein synthesis and breakdown rates respond to added weight.
Measured protein content, RNA, and DNA in the anterior latissimus dorsi muscle over 58 days
Used continuous-infusion technique with [14C]proline to assess protein synthesis
Calculated protein degradation from the difference between synthesis and growth rates.
Protein content increased by 140% over 58 days, along with similar increases in RNA and DNA.
The fractional rate of protein synthesis increased markedly, reflecting higher RNA content post-initial days.
Protein degradation rates remained elevated for at least 4 weeks, confirming ongoing muscle remodeling.

Structured PICO

Population

Adult fowl (anterior latissimus dorsi muscle)

Intervention

Attachment of a weight to one wing to induce hypertrophy

Outcome

Changes in rates of protein synthesis and breakdown, protein content, RNA and DNA contentssurrogate

In an adult fowl model, muscle stretch induced by weighting a wing leads to marked increases in both protein synthesis and degradation during skeletal muscle hypertrophy.

Discussion

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Implication

Muscle stretch elevates protein turnover in avian hypertrophy; extends mechanistic understanding but leaves open mammalian translation.

Cite This Study

Laurent et al. (1978) studied this question.

synapsesocial.com/papers/6a76a925f6b553d308adf44c https://doi.org/10.1042/bj1760407

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Turnover of muscle protein in the fowl. Changes in rates of protein synthesis and breakdown during hypertrophy of the anterior and posterior latissimus dorsi muscles

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Turnover of muscle protein in the fowl. Changes in rates of protein synthesis and breakdown during hypertrophy of the anterior and posterior latissimus dorsi muscles

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider