Why the study?
Does gestational mumps virus infection cause endocardial fibroelastosis in a chicken model?
Does gestational mumps virus infection cause endocardial fibroelastosis in a chicken model?
Gestational mumps virus infection in a chicken model leads to early myocarditis followed by the development of endocardial fibroelastosis at 1 year of age.
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Supports mumps-myocarditis-EFE sequence in avian model; hypothesis-generating and leaves open human relevance.
A model of persistent gestational mumps virus infection has been developed in the chicken. Virus, inoculated into the yolk sac at 12 hours, persisted throughout fetal life and for a few days following hatch. Although virus was widely distributed in the fetus, inflammatory change occurred only in the heart. Myocarditis was detected initially at 18 days of fetal life, was most impressive at hatch, and resolved within 1 week after hatch. Examination of these chickens at 1 year of age revealed histological evidence of endocardial fibroelastosis.
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Geme et al. (1971) studied this question.
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