Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
January 7, 1997Circulation

Viral Infection of the Myocardium in Endocardial Fibroelastosis

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Is viral infection of the myocardium associated with endocardial fibroelastosis?

Population

29 patients with autopsy-proven endocardial fibroelastosis and 65 control samples

Comparison

Polymerase chain reaction or reverse… vs 65 control samples

Design

Case-control

Authors

JNJiyuan NiHebei Medical UniversityNBNeil E. BowlesNorthwestern UniversityYKYoung-Hwue KimBaylor College of Medicine

Discussion

Loading...

Member takes

Overview

Supports myocardial viral association with EFE; leaves open causal role and need for prospective studies.

Structured PICO

Is viral infection of the myocardium associated with endocardial fibroelastosis?

P
Population
29 patients with autopsy-proven endocardial fibroelastosis and 65 control samples
I
Intervention
Polymerase chain reaction (PCR) or reverse transcriptase-PCR analysis for viral genomes (enterovirus, adenovirus, mumps, cytomegalovirus, parvovirus, influenza, herpes simplex virus)
C
Comparator
65 control samples
O
Outcome
Presence of viral genome in myocardial samplessurrogate

The high prevalence of mumps and adenovirus genomes in myocardial samples of patients with endocardial fibroelastosis strongly supports a viral etiology for the disease.

Cite This Study

Ni et al. (1997) studied this question.

synapsesocial.com/papers/6a73b14014e943abc869ed72https://doi.org/10.1161/01.cir.95.1.133
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ENDOCARDIAL FIBROELASTOSIS AND THE MUMPS VIRUS1966 · 51 citations
  2. 2Fatal Mumps Myocarditis1984 · 8 citations
  3. 3A six-year study of coxsackievirus B infections in heart disease1974 · 125 citations
  4. 4Molecular detection and identification of enteroviruses using enzymatic amplification and nucleic acid hybridization1990 · 241 citations