February 17, 2005Clinical Infectious Diseases

Cytomegalovirus Infection of the Heart Is Common in Patients with Fatal Myocarditis

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Population

40 patients with fatal myocarditis fulfilling Dallas criteria, and 12 control subjects who died accidentally…

Design

Case-control

Authors

VKVille KytöGeneral Cardiology TVTytti VuorinenUniversity of Helsinki PSPekka SaukkoÅbo Akademi University

Discussion

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Implication

May prompt CMV testing in severe myocarditis; leaves open antiviral efficacy pending prospective trials.

Structured PICO

Population

40 patients (20 men, 20 women; median age 49 years) with fatal myocarditis fulfilling Dallas criteria, and 12 control subjects who died accidentally in Finland (1970-1998).

Comparator

12 control subjects who died accidentally

Outcome

Detection of viral genomes (adenovirus, cytomegalovirus, enterovirus, human herpesvirus 6, influenza A and B viruses, parvovirus B19, and rhinovirus) in heart samples using PCR and in situ hybridizationsurrogate

Cytomegalovirus is the most common viral finding in immunocompetent patients with fatal myocarditis, highlighting a potential therapeutic target for severe acute myocarditis.

Cite This Study

Kytö et al. (2005) studied this question.

synapsesocial.com/papers/6a7218d72fdcb5703edb87ae https://doi.org/10.1086/427804

Topics

Myocarditis

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Cytomegalovirus Infection of the Heart Is Common in Patients with Fatal Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Cytomegalovirus Infection of the Heart Is Common in Patients with Fatal Myocarditis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider