Population
Actin modified to block polymerization
Comparison
Crystallization in the adenosine 5'-diphosphate… vs Previous ATP-actin structures from complexes…
Design
Preclinical
Authors
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Enables future actin complex structures; leaves open physiological validation in cellular contexts.
The successful crystallization of monomeric actin in the ADP state reveals a marked conformational change in subdomain 2, opening the way to future structure determinations of actin complexes.
Otterbein et al. (2001) studied this question.
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