Why the study?
Are elastin peptide concentrations in body fluids elevated in patients with COPD and smokers compared to healthy nonsmokers?
Population
28 subjects including patients with chronic obstructive pulmonary disease, healthy smokers, and healthy…
Comparison
Measurement of elastin peptide concentrations in… vs Comparison among COPD patients, healthy smokers…
Design
Cross-sectional
Authors
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May support elastin peptides as COPD biomarkers; hypothesis-generating and requires prospective validation before clinical use.
Are elastin peptide concentrations in body fluids elevated in patients with COPD and smokers compared to healthy nonsmokers?
Elastin peptide concentrations measured by ELISA in urine and plasma are elevated in COPD patients, suggesting utility as a noninvasive biomarker for elastin degradation in emphysema.
Schriver et al. (1992) studied this question.
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