Why the study?
Does N-acetylcysteine potentiate doxorubicin-induced ATM and p53 activation in cultured ovarian cancer cells?
Population
Cultured ovarian cancer cells (CaOV3)
Comparison
Doxorubicin with or without pretreatment with… vs Basal level (control) or doxorubicin alone
Design
Preclinical
Authors
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NAC may enhance doxorubicin in ovarian cancer cells; hypothesis-generating and requires in vivo and clinical validation.
Does N-acetylcysteine potentiate doxorubicin-induced ATM and p53 activation in cultured ovarian cancer cells?
N-acetylcysteine potentiates doxorubicin-induced ATM and p53 activation in ovarian cancer cells, suggesting that removal of oxidants by antioxidants may enhance the efficacy of doxorubicin.
Brum et al. (2012) studied this question.
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