Key result
Coadministration of the GSK-3 inhibitor SB216763 with doxorubicin restored Nrf2 protein expression, reduced oxidative damage, and preserved ovarian follicles and hormone levels in mice.
Why the study?
Doxorubicin causes gonadotoxicity via oxidative stress, and GSK-3 inhibition can regulate oxidative stress, but whether GSK-3 inhibition protects the ovary against DOX-induced oxidative damage remained to be assessed.
Does GSK-3 inhibition with SB216763 prevent doxorubicin-induced oxidative damage to the ovarian reserve in mice?
Population
Mice with DOX-induced ovarian oxidative damage
Comparison
DOX plus GSK-3 inhibitor SB216763 vs DOX alone vs control
Design
Preclinical animal study
Authors
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Hypothesis-generating for GSK-3 inhibition in doxorubicin ovarian protection; human trials required before clinical consideration.
Does GSK-3 inhibition with SB216763 prevent doxorubicin-induced oxidative damage to the ovarian reserve in mice?
GSK-3 inhibition with SB216763 protects against doxorubicin-induced ovarian damage and preserves ovarian reserve in a mouse model.
Niringiyumukiza et al. (2019) studied Doxorubicin-induced ovarian damage. SB216763 (GSK-3 inhibitor) vs. Doxorubicin alone and control was evaluated. Coadministration of the GSK-3 inhibitor SB216763 with doxorubicin restored Nrf2 protein expression, reduced oxidative damage, and preserved ovarian follicles and hormone levels in mice.
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